AGENDA

MONDAY AUGUST 21st, 2017

TUESDAY AUGUST 22nd, 2017

WEDNESDAY AUGUST 23rd, 2017

THURSDAY AUGUST 24th, 2017

MONDAY AUGUST 21ST, 2017

All Day

Understand Your Genome® Symposium – Illumina

Understand Your Genome® (UYG) provides a unique, hands-on opportunity to learn about the information encoded within your own genome. This educational symposium is designed to engage individuals to learn about the untapped potential of DNA to improve health care and management. It is a dynamic community of individuals who are paving the way for precision medicine, and a new standard of care. Click here for more information

7:30 – 9:00am

Registration for Workshops – Indigo Ballroom

8:00 – 9:00am

Breakfast Buffet – Indigo West Foyer

9:00 – 12:00noon

Cancer Evolution and Precision Oncology – Li Liu, M.D. – Indigo 202 A

Cancer, as an evolutionary process, is born with a heterogeneous and dynamic nature. Precision identification and intervention of cancer shall consider the past, present and future of each tumor. With NextGen sequencing technologies, we can now catch a glimpse of this evolutionary process. However, is it possible to use these static snapshots to help hit the moving target? How close or how far are we to apply it in clinical practice? In this interactive workshop, we will:

  • Introduce the basic concepts of molecular evolution and cancer subclones

  • Examine the relationship of host, tumor and intervention as key players in an ecological system

  • Decipher the evolutionary process of a drug-resistant tumor sample with NextGen sequencing data and computational modeling

  • Discuss the promises and challenges of cancer evolution in precision oncology

9:00 – 12:00noon

Precision Medicine 101 – Genomic Literacy – Jeanette McCarthy – Indigo 202 B

Genomic literacy is essential for all members of the health care ecosystem, not just health care providers, but those involved in regulatory, legal, financial and technical aspects of precision medicine as well. Whether you are new to or already working in the field of precision medicine, this interactive workshop will strengthen your foundational understanding of the field. This workshop will cover

  • Human genomics (DNA, genes and genetic variation)

  • Genomics, heredity and disease (the link between genetic variation and disease)

  • Genomics in medical practice (current clinical applications of genetic testing)

  • Risks, regulation and ethics of genetic testing

12:00 – 1:00pm

Boxed Lunch

1:00 – 4:00pm

Integration of Pharmacogenomics in Patient-Centered Healthcare – Adrijana Kekic – 204B

This workshop is intended for clinicians, researchers, and payers interested in results of implementation of pharmacogenomics in patient-centered model of care.

The workshop is focused on sharing examples of lessons learned from the clinic. Areas of practice covered will include cardiology, psychology, transplant, anesthesia and palliative care. The intent of this workshop is to provide an interactive forum for discussion on the role and integration of PGx at bedside, with specific emphasis on chronic disease management, polypharmacy, therapy selection and pre-emptive prescribing. Goals of the Workshop

  • Discuss the impact of PGx in patient centered model of care.
  •  Increase enthusiasm for implanting PGx testing in the clinic.
  • Encourage collaborations in PGx discoveries and clinical implementations.

1:00 – 4:00pm

Establishing the Evidence Base and Quality Standards in Next Generation Sequencing – Paul Langley – Indigo 204 A

The goal of this workshop is to detail the required framework for establishing the evidence base and quality reporting standards in next generation sequencing (NGS). Accepting NGS as an integral part of patient management in physician practice will only succeed if it can be demonstrated through real time systematic observations that claims made for improved outcomes and lower costs in target patient populations can be validated and reported to the physician and NGS assay vendor in a meaningful time frame. Reporting the results of an NGS assay with suggestions for potential therapy matching to gene expression is only a first step. An assay vendor needs to work with the practice to ensure improved patient care. Participants in the workshop will:

  • Consider the minimum evidence standards required to support adoption of NGS interventions

  • Consider the information framework required to support feedback in NGS interventions

  • Consider options for quality incentive programs to support adoption of NGS interventions as part of physician practice under the Medicare Access and CHIP Reauthorization Act

  • Consider complementary data elements capturing co-morbidities and adverse events to support NGS interventions in target populations

3:00 – 6:00pm

PMLS 2017 Registration Open – Indigo West Foyer

5:30 – 8:30pm

Opening Reception – Indigo Terrace

TUESDAY AUGUST  22ND, 2017

7:00-8:00am

Breakfast Buffet

8:00-8:15am

Chairperson’s Opening Remarks

8:15–8:45am

Keynote Address

8:45–9:45am

Opening Plenary – A World Without Disease

Werner Verbiest, Janssen Diagnostics,  Thomas Bock, HeritX

9:45–10:45am

Tissue is Still the Issue – A Paradigm Shift in Biopsy Philosophy

 Mark Boguski Inspirata, Emanuel Petricoin III George Mason University

10:45–11:00am

Coffee Break

11:00–12:00 noon

The Multi Omic Revolution- Bringing More Diversification and Data to Precision Medicine

Alan Sachs, Thermo Fisher Scientific

12:00–12:45pm

Biomarker Purgatory – Why so many Publications but so few Successes?

Robert Loberg, Amgen, Razelle Kurzrock UCSD, Karen Sasser Janssen

12:45–1:30pm

Buffet Lunch

1:30–2:30pm

How Do We implement Precision Medicine in an Era of Intensifying Scrutiny on Costs and Value?

John Rudan – Queen’s University, Ontario, Jeremy Nicholson – Imperial College, Mary Maxon – Lawrence Berkeley National Laboratory, Gary Suizdak – UCSD

2:30–3:15pm

Is Regulatory Agility an Oxymoron?

Elizabeth Mansfield – Grail, James Czaban – DL Piper

3:15–4:15pm

Disruptive Precision Therapeutics – Where are we now and where are we headed?

Yves Lussier – University of Arizona, Nigam Shah – Stanford University, Marc Williams – Geisinger

4:15–4:45pm

Coffee Break

4:45–5:45pm

Access and Affordability of Advances in PM and Disparities of Care

Lynn Dressler – Mission Health, Lee Schwartzberg – Univ. of Tennessee, Kathryn Phillips – UCSF

5:45–6:30pm

Circulating Exosomes – New Diagnostics for Disease Detection & Treatment Monitoring

Free Evening – Enjoy the sights and sounds of San Diego’s broad array of restaurants and nightlife

WEDNESDAY AUGUST 23RD, 2017

7:30-8:25am

Breakfast Buffet

8:25–8:30am

Day 1 Recap

8:30–9:00am

Jeremy Nicholson – Imperial College London

9:00–9:45am

Measuring and Paying for Value in the Age of Precision Medicine

Randy Burkholder – PhRMA

9:45–10:30am

Reawakening a Broken Brain

10:30–11:00am

Coffeee Break

11:00–12:00noon

Connecting Genotype and Phenotype: Using Proteomics to Bring Together
the Personal and the Precise

Larry Gold, Somalogic, Jun Wang, iCarbonX

12:00–12:45pm

Patient Advocate Session

Bryce Olson – Intel, Peter Kapitien – Inspire2Live, Amy Lynne Volker – Nicholas Volker – One in a Billion Foundation

12:45–1:30pm

Buffet Lunch

1:30–2:30pm

Smart Machines and Slow Brains – The Role of Deep Learning and Artificial Intelligence in Precision Medicine

Atul Butte – UCSF, Simon Kos – Microsoft, Thomas Wilckens – InnVentis

2:30–3:30pm

Invasion of the Body Trackers – Do Wearables, Sensors, and Remote Health Monitoring Enhance Care and Outcomes?

3:30–4:00pm

Coffee Break

4:00–5:00pm

Digital Genomics – The Last Mile Between Sequencing and the Clinic

Bruce Quinn, Enrico Capobianco – Uni of Miami,

5:00–6:00pm

Mission Possible – Moving Diagnostics to the Forefront of Precision Medicine

Tricia Carrigan – Bayer, Mara Aspinall – Health Catalysts, Hannah Mamuszka – Alva10

4:50–5:45pm

Do Mobile Apps and Web Based Healthcare Sites for Consumers Enhance Care and Outcomes?

5:50–6:50pm

Roundtables

  • Telemedicine
  • Medication Non-Adherence
  • Medical Imaging & Pathology – will machine intelligence replace human specialists?
  • Defining Value in Biomedical Innovation – metrics, costs, and outcomes
  • Precision Medicine and Infectious Diseases – new diagnostics for global surveillance
  • Data Mining of real world evidence from large populations: the fastest route to routine PM?
  • Mental Illness – a neglected ‘orphan’ in precision medicine?
  • Security of Healthcare data in the Cloud

7:00–10:00pm

Evening Reception

THURSDAY AUGUST 24TH, 2017

7:45–8:30am

Breakfast Buffet

8:30–9:00am

Fireside Chat

9:00–10:00am

Trials & Tribulations – The Demise of the Randomized Clinical Trial

10:00–10:45am

Minority Report – Ethnic Diversity and the Real Promise for Precision Medicine

10:45–11:15am

Coffee Break

11:15–12:15pm

Precision Planet – A Global View of Population Health

12:15–1:00pm

The Invisible Ecosystem – Illuminating the Microbiome with Precision Medicine

Karen Nelson JCVI

1:00–1:45pm

Buffet Lunch

1:45–2:30pm

Brave New Future: Genome Editing & Regulatory Oversight

2:30–3:15pm

Nothing Ventured Nothing Gained – How San Diego Became a Breeding Ground
for Success.

Matthew Sanford – SDEDC, Felix Frueh

3:15–3:45pm

Closing Keynote – Dr. George Poste